Forget Shopify (TSX:SHOP): This Tiny TSX Stock Has Returned 1,900% in 2020

Amid the chaos of the coronavirus pandemic, it’s easy to forget about other diseases. That’s why we missed the epic rally of this tiny TSX stock.

This year has all been about wearing masks, maintaining social distancing, and staying at home. As this coronavirus pandemic overshadowed everything, it’s easy to forget about other dreadful diseases. And that’s why many of us missed the epic rally of the tiny TSX stock Trillium Therapeutics (TSX:TRIL)(NASDAQ:TRIL).

Top TSX stock: Trillium Therapeutics

Trillium Therapeutics is a $1.6 billion biotech company that develops innovative therapies for the treatment of cancer. Trillium stock was trading at a little over than $1 back in January, and the stock crossed $27 levels in late November.

That’s more than a 1,900% gain within a year. If you had invested $10,000 in this TSX stock early this year, you would have made $200,000 by the end of November.

Tech giant Shopify stock has returned 160% this year. The gains of even the top-performing tech stock look smaller now. In comparison, the TSX Composite Index has returned 4% in 2020.

What drove the rally?

Trillium’s science focuses on CD47, a molecule that tumours use to evade the immune system. According to the biotech company, it aims to reveal the tumour cells and make them visible to the body’s immune system using CD47.

The company has two drug candidates that have already shown promising results in the phase-one trials.

Why is this big? Beyond the recent phase-one trials’ encouraging results, some bigger pharma companies could be closely eyeing these developments. Back in March, Gilead Sciences bought a biotech firm called Forty Seven for US$5 billion. It was working on the treatment of cancer using the same CD47 approach.

The global pharma giant Pfizer has invested $25 million in Trillium in September 2020.

Financials and outlook

Beyond its innovative approach to treat cancer, Trillium is currently a loss-making venture. For the nine months ended September 30, 2020, the company reported total revenues of $115,000, a fall of more than 7% compared to a year-ago period. Loss notably widened to $173 million in the same period.

The company is sufficiently capitalized with $300 million cash to take on further trials. It intends to take the phase-two program in heme and solid tumour malignancies next year.

Importantly, the financials and valuation would take a sidestep if the late-stage clinical trials continue to show promising results. Gilead’s recent purchase created enthusiasm among biotech companies, which might help Trillium stock to trade higher going into 2021.

While the world is busy observing the COVID-19 vaccine developments, this cancer specialist went ahead and significantly outperformed broader markets. Pfizer and Moderna are spearheading the COVID-19 vaccine race. Moderna stock has risen almost 730%, while Pfizer is up just 10% this year.

After the steep rally, Trillium stock has fallen more than 40% so far in December. Investors can expect extremely high volatility with this stock, given the underlying uncertainties and its size. Investors with a big appetite for its large swings can consider Trillium stock for superior returns.

Fool contributor Vineet Kulkarni has no position in any of the stocks mentioned. Tom Gardner owns shares of Shopify. The Motley Fool owns shares of and recommends Gilead Sciences, Shopify, and Shopify.

More on Stocks for Beginners

A worker gives a business presentation.
Dividend Stocks

The Bank of Canada Just Spoke: Here’s What I’d Buy in a TFSA Now

With the Bank of Canada on pause, TFSA investors can shift from rate-watching to owning businesses that compound through ordinary…

Read more »

Child measures his height on wall. He is growing taller.
Stocks for Beginners

Why I’m Never Selling This ETF in My Retirement Account

Retirement feels harder for most Canadians, and VGRO is built as a simple, low-cost “set it and stick with it”…

Read more »

A worker gives a business presentation.
Energy Stocks

Rates Are Stuck: 1 Canadian Dividend Stock I’d Buy Today

Side hustles are booming, but a steady dividend stock like Emera could be the quieter “second income” that doesn’t need…

Read more »

rising arrow with flames
Stocks for Beginners

Market on Fire: How to Invest When the TSX Refuses to Slow Down

A red-hot market does not have to mean reckless investing when you can still focus on real business momentum.

Read more »

man looks worried about something on his phone
Dividend Stocks

Rogers Stock: Buy, Sell, or Hold in 2026?

Rogers looks like a classic “boring winner” but price wars, debt, and heavy network spending can still bite.

Read more »

Yellow caution tape attached to traffic cone
Tech Stocks

3 Popular Stocks That Could Wipe Out a $100,000 Nest Egg

Popular “story stocks” can turn dangerous fast when expectations are high and results slip, so these three deserve extra caution.

Read more »

Start line on the highway
Stocks for Beginners

Your First Canadian Stocks: How New Investors Can Start Strong in 2026

New investors considering what Canadian stocks to start with should consider these three picks for growth and income.

Read more »

pig shows concept of sustainable investing
Dividend Stocks

A 5% Dividend Stock is My Top Pick for Immediate Income

Brookfield Infrastructure Partners L.P. is a reasonable buy here for immediate income and long-term growth, but investors should be ready…

Read more »