Forget Shopify (TSX:SHOP): This Tiny TSX Stock Has Returned 1,900% in 2020

Amid the chaos of the coronavirus pandemic, it’s easy to forget about other diseases. That’s why we missed the epic rally of this tiny TSX stock.

This year has all been about wearing masks, maintaining social distancing, and staying at home. As this coronavirus pandemic overshadowed everything, it’s easy to forget about other dreadful diseases. And that’s why many of us missed the epic rally of the tiny TSX stock Trillium Therapeutics (TSX:TRIL)(NASDAQ:TRIL).

Top TSX stock: Trillium Therapeutics

Trillium Therapeutics is a $1.6 billion biotech company that develops innovative therapies for the treatment of cancer. Trillium stock was trading at a little over than $1 back in January, and the stock crossed $27 levels in late November.

That’s more than a 1,900% gain within a year. If you had invested $10,000 in this TSX stock early this year, you would have made $200,000 by the end of November.

Tech giant Shopify stock has returned 160% this year. The gains of even the top-performing tech stock look smaller now. In comparison, the TSX Composite Index has returned 4% in 2020.

What drove the rally?

Trillium’s science focuses on CD47, a molecule that tumours use to evade the immune system. According to the biotech company, it aims to reveal the tumour cells and make them visible to the body’s immune system using CD47.

The company has two drug candidates that have already shown promising results in the phase-one trials.

Why is this big? Beyond the recent phase-one trials’ encouraging results, some bigger pharma companies could be closely eyeing these developments. Back in March, Gilead Sciences bought a biotech firm called Forty Seven for US$5 billion. It was working on the treatment of cancer using the same CD47 approach.

The global pharma giant Pfizer has invested $25 million in Trillium in September 2020.

Financials and outlook

Beyond its innovative approach to treat cancer, Trillium is currently a loss-making venture. For the nine months ended September 30, 2020, the company reported total revenues of $115,000, a fall of more than 7% compared to a year-ago period. Loss notably widened to $173 million in the same period.

The company is sufficiently capitalized with $300 million cash to take on further trials. It intends to take the phase-two program in heme and solid tumour malignancies next year.

Importantly, the financials and valuation would take a sidestep if the late-stage clinical trials continue to show promising results. Gilead’s recent purchase created enthusiasm among biotech companies, which might help Trillium stock to trade higher going into 2021.

While the world is busy observing the COVID-19 vaccine developments, this cancer specialist went ahead and significantly outperformed broader markets. Pfizer and Moderna are spearheading the COVID-19 vaccine race. Moderna stock has risen almost 730%, while Pfizer is up just 10% this year.

After the steep rally, Trillium stock has fallen more than 40% so far in December. Investors can expect extremely high volatility with this stock, given the underlying uncertainties and its size. Investors with a big appetite for its large swings can consider Trillium stock for superior returns.

Fool contributor Vineet Kulkarni has no position in any of the stocks mentioned. Tom Gardner owns shares of Shopify. The Motley Fool owns shares of and recommends Gilead Sciences, Shopify, and Shopify.

More on Stocks for Beginners

Real estate investment concept with person pointing on growth graph and coin stacking to get profit from property
Dividend Stocks

2 Canadian Stocks to Buy if Mortgage Rates Stay High

High mortgage rates can squeeze consumers and cool housing, so these two TSX stocks are framed as ways to stay…

Read more »

shopper carries paper bags with purchases
Dividend Stocks

Inflation Just Hit 2.4%, but These 2 Canadian Stocks Still Look Like Buys

It's time to consider stocks that can keep rising even if interest rates stay high for a while.

Read more »

Top TSX Stocks

If I Could Only Buy and Hold a Single Stock, This Would Be It

Bank of Nova Scotia is a compelling buy-and-hold stock thanks to its stability, global reach, and reliable dividend income.

Read more »

Senior uses a laptop computer
Tech Stocks

A Year Later: 3 Canadian Stocks I Still Want in My TFSA

Three TFSA-friendly compounders still look like they’re executing a year later, even if none of them is truly “cheap.”

Read more »

woman looks out at horizon
Dividend Stocks

5 Canadian Stocks I’d Feel Good About Holding for the Next 10 Years

Here's why these five Canadian stocks are some of the best picks on the TSX, not to just buy now,…

Read more »

Warning sign with the text "Trade war" in front of container ship
Stocks for Beginners

2 Canadian Stocks That Could Surprise Investors During Trade Turbulence

These five “boring” TSX stocks focus on essentials and recurring demand, which can make them useful holds in 2026.

Read more »

frustrated shopper at grocery store
Dividend Stocks

5 TSX Stocks to Buy for a Calm, Boring, Winning Portfolio

These five “boring” TSX stocks focus on essentials and recurring demand, which can make them useful holds in 2026.

Read more »

Canadian Red maple leaves seamless wallpaper pattern
Dividend Stocks

The Canadian Stocks I’d Be Most Comfortable Buying and Holding in a TFSA Forever

I'd be most comfortable buying and holding blue-chip Canadian dividend stocks in a TFSA forever.

Read more »