This Tiny Canadian Stock Could Skyrocket if That Drug Trial Succeeds

This pharmacy stock may be small, but it could become quite mighty.

Amy Legate-Wolfe

Author Bio Amy became interested in investing in 2018 after having her first daughter. After receiving a masters degree in journalism from Western University, she became frustrated that the finance industry remained a confusing place for Canadians like her: new parents, millennials, and other young people who needed to understand their finances. Now, Amy focuses on tech companies and renewable energy for growth opportunities, coupling that with long-term investing strategies and equities. She also provides investors with a daily newsletter, Canada Stock Digest, for daily market updates. Her work can also be found at Canada's National Observer, where she writes on the business side of climate action. Before joining Motley Fool Canada, Amy wrote for major news organizations including HuffPost, CTVNews.ca, and CBC. When she’s not researching investing strategies, Amy’s time is pretty much monopolized by her two wild daughters, but in what little spare time she has she loves to do yoga, go on walks with her dog, and travel with her husband. Social Media Follow Amy on LinkedIn and Canada Stock Digest. Favorite Investment Quote “October: This is one of the particularly dangerous months to speculate in stocks. The others are July, January, September, April, November, May, March, June, December, August and February.” – Mark Twain

Published August 26, 2025 4:10 pm EDT

| More on: NGEN

Every once in a while, a tiny Canadian biotech comes along with the kind of story that makes income seekers and risk-takers sit up and pay attention. NervGen Pharma (TSXV: NGEN) is one of those names. This Canadian stock is developing NVG-291, a potential first-in-class drug aimed at repairing nervous system damage caused by spinal cord injuries. For a Canadian stock that’s worth just over $200 million, the upside from a successful trial could be enormous.

senior man and woman stretch their legs on yoga mats outside — Source: Getty Images

Why NervGen

The past year has been anything but quiet for NervGen. Shares hit a 52-week high of $7.05 before tumbling back to the $2.80 range. That kind of volatility is common in biotech, where a single press release can make or break fortunes. NervGen’s valuation has swung with the headlines, particularly as investors followed results from the CONNECT SCI study. In July, the company reported positive topline results from the chronic cohort of its Phase 1b/2a trial. NVG-291 not only met its primary endpoint but also showed promising signs of improved hand function, a critical quality-of-life metric for spinal cord injury patients.

That news sparked optimism, but it also came with leadership changes. NervGen’s long-time CEO stepped down, and board chair Adam Rogers took over as interim chief executive. Management turnover in the middle of clinical development is always a risk, but it doesn’t change the fact that the science appears to be moving in the right direction.

Into earnings

From a financial perspective, NervGen is still in the early stages. The Canadian stock reported a net loss of about $25.6 million over the past year, with operating cash flow of negative $17.7 million. That’s typical for a biotech without commercial products, but it means funding is a constant question. NervGen had around $14.5 million in cash at the end of March, which buys it some time but not a long runway. Unless it secures a partnership or new financing, the Canadian stock will likely need to raise more money to keep trials moving.

Despite the risks, the opportunity is hard to ignore. NervGen received Fast Track designation from the FDA for NVG-291 in spinal cord injury. The Canadian stock also holds Orphan Designation in Europe, a status that can offer market exclusivity and financial incentives if the drug is approved. Beyond spinal cord injury, NervGen is exploring NVG-291’s potential in other conditions like multiple sclerosis. Meanwhile its second pipeline candidate, NVG-300, is being tested in preclinical models of ischemic stroke. Each of these programs represents a possible expansion of the company’s value if early results are positive.

Considerations

Investors should be clear-eyed about the risks. NervGen has no revenue, negative cash flow, and a long road between promising trial data and an approved drug. Clinical failures happen, and even if the science holds up, manufacturing, funding, and regulatory hurdles remain. Still, for those willing to tolerate uncertainty, the reward could be significant. A successful late-stage trial or a breakthrough partnership with a larger pharmaceutical company could send this Canadian stock soaring well beyond its current levels.

For now, NervGen sits in that high-risk, high-reward corner of the market where fortunes are made and lost on a single trial. The Canadian stock already demonstrated meaningful progress with NVG-291. Yet investors will need patience and a strong stomach to hold on through the ups and downs. If the upcoming regulatory conversations and subacute trial data confirm the early promise, NervGen could transform not just its market cap but also the lives of patients living with spinal cord injury.

Bottom line

NervGen’s stock trades today at around $2.87, giving it a market cap near $210 million at writing. The Canadian stock has no revenue, a price-to-book ratio over 150, and a return on equity of negative 253%. For most investors, those numbers are red flags. But for those chasing the possibility of a medical breakthrough, NervGen remains one of Canada’s most intriguing tiny stocks, one that could skyrocket if its drug trial succeeds. Especially from a small stake in this volatile stock.